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Gap19
CAS No. 1507930-57-5
Gap19 ( —— )
产品货号. M30262 CAS No. 1507930-57-5
Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥547 | 有现货 |
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| 5MG | ￥900 | 有现货 |
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| 10MG | ￥1404 | 有现货 |
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| 25MG | ￥2714 | 有现货 |
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| 50MG | ￥3974 | 有现货 |
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| 100MG | ￥5666 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
生物学信息
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产品名称Gap19
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.
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产品描述Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.(In Vitro):Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo. (In Vivo):Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth.
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体外实验Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo.
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体内实验Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth. Animal Model:C57/BL6 mice Dosage:25 mg/kg Administration:IV; 10 min before ligation Result:Significantly reduced the infarct size by approximately one-fifth.
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同义词——
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点Gap Junction Protein
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受体Cx43 Hemichannel
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研究领域——
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适应症——
化学信息
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CAS Number1507930-57-5
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分子量1161.44
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分子式C55H96N14O13
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称Sequence:{Lys}{Gln}{Ile}{Glu}{Ile}{Lys}{Lys}{Phe}{Lys}
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
Boengler K, et al. Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013 Jun 6;4:73.
产品手册
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TAT-Gap19
Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19. Active in vivo. Brain penetrant.
