
Gamma-Oryzanol
CAS No. 11042-64-1
Gamma-Oryzanol ( —— )
产品货号. M10400 CAS No. 11042-64-1
γ 谷维素是从米糠油中分离出来的天然营养提取物,含有甾醇和阿魏酸的混合物。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
500MG | ¥332 | 有现货 |
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1G | ¥389 | 有现货 |
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生物学信息
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产品名称Gamma-Oryzanol
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述γ 谷维素是从米糠油中分离出来的天然营养提取物,含有甾醇和阿魏酸的混合物。
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产品描述Gamma Oryzanol is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the destruction of free radicals in the skin. It has recently been researched for its ability to slow the progress of melanin pigmentation by intercepting the ultraviolet rays at the skin's surface and hindering their transmission.
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体外实验γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT 3a (IC50=22.3 μM) and DNMT 3b (maximum inhibition 57%). In contrast, the inhibitory activity of Ferulic acid, a metabolite of γ-Oryzanol, is much lower than that of γ-Oryzanol. Furthermore, γ-Oryzanol acts as a partial antagonist against ERRγ, which primarily serves as a positive regulator for DNMT1 production, and consequently decreased the activity of DNMT1.
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体内实验The brown rice-specific bioactive component γ-Oryzanol, a mixture of ferulic acid ester and several phytosterols, attenuates the preference for dietary fat via a decrease in hypothalamic endoplasmic reticulum (ER) stress. γ-Oryzanol ameliorates HFD-induced DNA hypermethylation of the promoter region of D2R in the striatum of mice. γ-Oryzanol might regulate levels of DNMTs in a striatum-specific manner. γ-Oryzanol partially decreases ERRγ activity (an approximately 40% reduction of the innate value). Oral administration of γ-Oryzanol to male mice by gavage significantly attenuates the preference for an HFD (93% of the values for vehicle-treated mice), resulting in an apparent attenuation of body weight gain.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number11042-64-1
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分子量602.9
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分子式C40H58O4
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纯度>98% (HPLC)
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溶解度Soluble in Chloroform
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SMILESCC(CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CCC34C2CCC5[C@]3(C4)CC[C@@H](C5(C)C)OC(=O)/C=C/C6=CC(=C(C=C6)O)OC)C)C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Rao YP, et al. Biochem Biophys Res Commun. 2016 Oct 28;479(4):747-752.
产品手册




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