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Gamithromycin
CAS No. 145435-72-9
Gamithromycin ( ML-1709460 )
产品货号. M11956 CAS No. 145435-72-9
具有抗菌活性的大环内酯类化合物。
纯度: >98% (HPLC)
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规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥316 | 有现货 |
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5MG | ¥446 | 有现货 |
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10MG | ¥721 | 有现货 |
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25MG | ¥1288 | 有现货 |
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50MG | ¥2195 | 有现货 |
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100MG | ¥3572 | 有现货 |
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500MG | ¥7995 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Gamithromycin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述具有抗菌活性的大环内酯类化合物。
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产品描述A macrolide compound with antibacterial activity.(In Vitro):The MIC values in serum are significantly lower than those in artificial medium; at an initial inoculum size of 106 cfu/mL, these are 64-, 8- and 64-fold lower for gamithromycin, tylosin and tilmicosin, respectively, against MmmSC strain B237 in serum compare to artificial medium. A similar pattern emerges for Tan8. Heat-inactivation of serum results in an MIC for gamithromycin that is higher than in either non-treated serum or artificial medium.(In Vivo):The proportion of foals that recover without the need for a change in treatment is significantly (P<0.048) higher for foals treated with Gamithromycin (GAM) (38 of 40; 95%) or AZM-RIF (39 of 40; 98%) compare to control foals (32 of 41; 78%). The clinical scores, number of abscesses and the abscess scores after 1 and 2 weeks of treatment are significantly lower for foals treated with Gamithromycin (GAM) or AZM-RIF compare to control foals. The WBC count of foals treated with Gamithromycin (GAM) is significantly higher than that of foals treated with AZM-RIF on week 3 of treatment.
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体外实验The MIC values in serum are significantly lower than those in artificial medium; at an initial inoculum size of 106 cfu/mL, these are 64-, 8- and 64-fold lower for gamithromycin, tylosin and tilmicosin, respectively, against MmmSC strain B237 in serum compare to artificial medium. A similar pattern emerges for Tan8. Heat-inactivation of serum results in an MIC for gamithromycin that is higher than in either non-treated serum or artificial medium.
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体内实验The proportion of foals that recover without the need for a change in treatment is significantly (P<0.048) higher for foals treated with Gamithromycin (GAM) (38 of 40; 95%) or AZM-RIF (39 of 40; 98%) compare to control foals (32 of 41; 78%). The clinical scores, number of abscesses and the abscess scores after 1 and 2 weeks of treatment are significantly lower for foals treated with Gamithromycin (GAM) or AZM-RIF compare to control foals. The WBC count of foals treated with Gamithromycin (GAM) is significantly higher than that of foals treated with AZM-RIF on week 3 of treatment.
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同义词ML-1709460
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number145435-72-9
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分子量777.04
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分子式C40H76N2O12
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纯度>98% (HPLC)
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溶解度Soluble in DMSO
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SMILESO=C1[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(OC)C2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)N(CCC)C[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)O1
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化学全称(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-7-propyl-1-oxa-7-azacyclopentadecan-15-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mahendran SA, et al. Randomised positive control trial of NSAID and antimicrobial treatment for calf fever caused by pneumonia. Vet Rec. 2017 Apr 21. pii: vetrec-2016-104057.
产品手册
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