Gallopamil ( Methoxyverapamil )

产品货号. M26223 CAS No. 16662-47-8

Gallopamil 以浓度依赖性方式抑制酸分泌，IC50 为 10.9 μM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥583	有现货
10MG	￥988	有现货
25MG	￥1604	有现货
50MG	￥2406	有现货
100MG	￥3669	有现货
500MG	￥7995	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Gallopamil
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Gallopamil 以浓度依赖性方式抑制酸分泌，IC50 为 10.9 μM。
产品描述

Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist.(In Vivo):Gallopamil(5 min) significantly reduces systolic and diastolic blood pressure measured without markedly influencing heart rate. Gallopamil (0.2 mg/kg;i.v.) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF).
体外实验

——
体内实验

Gallopamil (Methoxyverapamil; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate. Animal Model:Male Wistar rats weighing 290-370 g Dosage:0.2 mg/kg Administration:i.v.; 5 minResult:Markedly reduced VT and totally prevented VF.
同义词

Methoxyverapamil
通路

GPCR/G Protein
靶点

Calcium Channel
受体

——
研究领域

——
适应症

——

化学信息

CAS Number

16662-47-8
分子量

484.637
分子式

C28H40N2O5
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 100 mg/mL (206.34 mM)
SMILES

COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Bolyard K, Gresens SE, Ricko AN, Sivey JD, Salice CJ. Assessing the toxicity of the "inert" safener benoxacor toward Chironomus riparius:Effects of agrochemical mixtures. Environ Toxicol Chem. 2017 Oct;36(10):2660-2670.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册