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Galangin

CAS No. 548-83-4

Galangin ( Galangin | Norizalpinin )

产品货号. M18786 CAS No. 548-83-4

Galangin 是芳基烃受体的激动剂/拮抗剂,并且还显示出对 CYP1A1 活性的抑制作用。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥243 有现货
10MG ¥381 有现货
25MG ¥624 有现货
50MG ¥996 有现货
100MG ¥1758 有现货
500MG ¥4398 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Galangin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Galangin 是芳基烃受体的激动剂/拮抗剂,并且还显示出对 CYP1A1 活性的抑制作用。
  • 产品描述
    Galangin inhibits Ca2+ entry into TRPC5 expressing cells and also induces autophagy.(In Vitro):Galangin (Norizalpinin) inhibits the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner. Galangin also inhibits the formation of DMBA-DNA adducts, and prevents DMBA-induced inhibition of cell growth. Galangin causes a potent, dose-dependent inhibition of CYP1A1 activity, as measured by ethoxyresorufin-O-deethylase activity, in intact cells and in microsomes isolated from DMBA-treated cells. Analysis of the inhibition kinetics by double-reciprocal plot demonstrates that galangin inhibits CYP1A1 activity in a noncompetitive manner. Galangin causes an increase in the level of CYP1A1 mRNA, indicating that it may be an agonist of the aryl hydrocarbon receptor, but it inhibits the induction of CYP1A1 mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD). Galangin also inhibits the DMBA- or TCDD-induced transcription of a reporter vector containing the CYP1A1 promoter. Galangin treatment inhibits cell proliferation and induced autophagy (130 μM) and apoptosis (370 μM). In particular, galangin treatment in HepG2 cells causes (1) an accumulation of autophagosomes, (2) elevated levels of microtubule-associated protein light chain 3, and (3) an increased percentage of cells with vacuoles. p53 expression is also increased. The galangin-induced autophagy is attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level.
  • 体外实验
    ——
  • 体内实验
    ——
  • 同义词
    Galangin | Norizalpinin
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ERK| NF-κB
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    548-83-4
  • 分子量
    270.2
  • 分子式
    C15H10O5
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 36 mg/mL; 133.21 mM
  • SMILES
    c1ccc(cc1)c1c(c(=O)c2c(cc(cc2o1)O)O)O
  • 化学全称
    3,5,7-Trihydroxy-2-phenyl-4-benzopyrone

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Wang Y, et al. Toxicology. 2014 Dec 4;326:9-17.
产品手册
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