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GZ389988
CAS No. 1788906-96-6
GZ389988 ( GZ-389988 | GZ 389988 )
产品货号. M12693 CAS No. 1788906-96-6
GZ389988 (GZ-389988) 是一种新型强效、选择性、局部递送的 TrkA 抑制剂，用于治疗骨关节炎；显示 TrkA、TrkB 和 TrkC 以及生长因子受体 cFMS (CSF1R) 的相似 IC50 值。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
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| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GZ389988
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GZ389988 (GZ-389988) 是一种新型强效、选择性、局部递送的 TrkA 抑制剂，用于治疗骨关节炎；显示 TrkA、TrkB 和 TrkC 以及生长因子受体 cFMS (CSF1R) 的相似 IC50 值。
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产品描述GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis; shows similar IC50 values for TrkA, TrkB and TrkC, and the growth factor receptor cFMS (CSF1R), GZ389988 is highly selective against a wide panel of other kinases; GZ389988 can significantly reduces local joint pain, without effect on ipsilateral joint pain; GZ389988 also is efficacious in the PGPS arthritis model, demonstrating a significant improvement of gait analysis scores following painful disease reactivation flares.Other Indication Phase 2 Clinical.
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体外实验——
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体内实验——
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同义词GZ-389988 | GZ 389988
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通路Tyrosine Kinase
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靶点Trk Receptor
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受体Trk Receptor
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number1788906-96-6
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分子量470.533
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分子式C26H26N6O3
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纯度>98% (HPLC)
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溶解度——
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SMILESNC1=NC2=CC(C3=CN(C)N=C3)=CN=C2N1CC4=CC=C(OCC5=CC=C(OC)C=C5)C(OC)=C4
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化学全称3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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