GW-870086
CAS No. 827319-43-7
GW-870086 ( —— )
产品货号. M22687 CAS No. 827319-43-7
GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB).
纯度: >98% (HPLC)
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥413 | 有现货 |
|
5MG | ¥648 | 有现货 |
|
10MG | ¥988 | 有现货 |
|
25MG | ¥1604 | 有现货 |
|
50MG | ¥2989 | 有现货 |
|
100MG | ¥4447 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称GW-870086
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB).
-
产品描述GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB). GW-870086 (10-100 nM) obviously increases fibronectin secretion. GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC50s, 9.6, 10.2). GW-870086 displays no effect on the MMTV reporter genes in A549 cells and has little or no activity at the oestrogen receptor, progesterone receptor, progesterone receptor, mineralocorticoid receptor, or androgen receptor. GW-870086 also has no effect on MMP2 secretion and does not enhance cellular myocilin.
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体glucocorticoid receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number827319-43-7
-
分子量559.64
-
分子式C31H39F2NO6
-
纯度>98% (HPLC)
-
溶解度——
-
SMILES[H][C@@]12C[C@@H](C)[C@](OC(=O)C3C(C)(C)C3(C)C)(C(=O)OCC#N)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
-
Acetylcorynoline
Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function.
-
7-Acetoxy-4-methylco...
7-Acetoxy-4-methylcoumarin is a fluorogenic substrate for carboxylesterase yielding a blue fluorescent solution upon cleavage.
-
Orexin A (human, rat...
Orexin A human, rat, mouse, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse has been used to study its effect on the functioning of porcine pancreatic islets. It has also been used as an orexin receptor 1 (OX1R) antagonist to study the effect of orexin systems in the effect of etonogestrel on respiratory response to prolonged metabolic acidosis.