GTS 21 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GTS 21 diHClide 是一种 nAChRs 激动剂。 nAChR 是通过与神经递质乙酰胆碱结合而激活的神经元受体蛋白。

GTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.(In Vitro):GTS-21 bound to human α4β2 nAChR (Ki=20 nM) 100-fold more potently than to humanα7-nAChR, and is 18- and 2-fold less potent than (-)-nicotine at human α4β2 and a7 nAChR, respectively.(In Vivo):GTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduces radiation induced histological signs of pulmonary injury.

GTS-21 bound to human α4β2 nAChR (Ki=20 nM) 100-fold more potently than to humanα7-nAChR, and is 18- and 2-fold less potent than (-)-nicotine at human α4β2 and a7 nAChR, respectively.

GTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduces radiation induced histological signs of pulmonary injury. Animal Model:C57BL6 mice were irradiated with 12 Gy to induce a mouse model of Radiation induced lung injury (RILI) Dosage:4 mg/kg Administration:I.p.; 1, 3, 7, 14 and 21 days Result:Reduces lung inflammatory infiltrate and fibrosis in radiation treated mice.

DMXB-A | DMBX-anabaseine

JAK/STAT Signaling

STAT

α4β2 nAChR

Inflammation/Immunology

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156223-05-1

381.3

C19H20N2O2·2HCl

>98% (HPLC)

DMSO : 16.5 mg/mL 43.27 mM

Cl.COc1ccc(/C=C\2/CCCN=C2c2cccnc2)c(OC)c1.Cl

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(-20℃)

With Ice Pack

≥ 2 years