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GSK598809
CAS No. 863680-45-9
GSK598809 ( GSK 598809;GSK-598809 )
产品货号. M16255 CAS No. 863680-45-9
GSK598809 (GSK-598809) is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9; displays >100-fold selectivity over D2 and H1 receptors.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2811 | 有现货 |
|
| 50MG | ￥11016 | 有现货 |
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| 100MG | ￥17739 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GSK598809
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GSK598809 (GSK-598809) is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9; displays >100-fold selectivity over D2 and H1 receptors.
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产品描述GSK598809 (GSK-598809) is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9; displays >100-fold selectivity over D2 and H1 receptors; significantly attenuates the expression of conditioned place preference (CPP) to nicotine and cocaine; potentiates the hemodynamic effects of cocaine in dogs, also increases mean arterial blood pressure and heart rate in vivo.
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同义词GSK 598809;GSK-598809
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通路GPCR/G Protein
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靶点Dopamine Receptor
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受体Dopamine Receptor
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number863680-45-9
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分子量481.51
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分子式C22H23F4N5OS
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纯度>98% (HPLC)
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溶解度DMSO : 83.33 mg/mL 173.06 mM
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SMILESCC1=C(OC=N1)C2=NN=C(N2C)SCCCN3CC4CC4(C3)C5=C(C=C(C=C5)C(F)(F)F)F
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化学全称1-[2-Fluoro-4-(trifluoromethyl)phenyl]-3-[3-[[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio]propyl]-3-azabicyclo[3.1.0]hexane
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Micheli F, et al. J Med Chem. 2010 Jan 14;53(1):374-91.
2. Appel NM, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):484-92.
3. Dodds CM, et al. Appetite. 2012 Aug;59(1):27-33.
4. Searle G, et al. Biol Psychiatry. 2010 Aug 15;68(4):392-9.
2. Appel NM, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):484-92.
3. Dodds CM, et al. Appetite. 2012 Aug;59(1):27-33.
4. Searle G, et al. Biol Psychiatry. 2010 Aug 15;68(4):392-9.
产品手册
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