GSK4027 ( GSK 4027;GSK-4027 )

产品货号. M13238 CAS No. 2079896-25-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GSK4027
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GSK4027 (GSK 4027, GSK-4027) is a potent, selective, cell-penetrant chemical probe of PCAF/GCN5 bromodomain with pKi of 8.9 for both.
产品描述

GSK4027 (GSK 4027, GSK-4027) is a potent, selective, cell-penetrant chemical probe of PCAF/GCN5 bromodomain with pKi of 8.9 for both; displays exceptional selectivity over the BET bromodomain family (>18000-fold selectivity over the BET family, >70-fold selectivity over the wider bromodomain families) and proof of cellular target engagement; GSK4027 is a useful chemical tool in elucidating the biological phenotype of PCAF/GCN5 bromodomain inhibition.
同义词

GSK 4027;GSK-4027
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

Inflammation/Immunology
适应症

——

CAS Number

2079896-25-4
分子量

377.29
分子式

C17H21BrN4O
纯度

>98% (HPLC)
溶解度

DMSO : 50 mg/mL 132.53 mM
SMILES

CN1C[C@@H](C2=CC=CC=C2)C[C@@H](NC3=C(Br)C(N(C)N=C3)=O)C1
化学全称

4-Bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one

1. Humphreys PG, et al. J Med Chem. 2017 Jan 26;60(2):695-709.

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产品手册

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