GSK3987

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GSK3987 是一种 LXR 配体。 GSK3987 将类固醇受体辅激活因子 1 募集至人 LXRalpha 和 LXRbeta，EC50 为 40 nM。

GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.(In Vitro):In primary human macrophages, GSK3987 (30, 100, 300, 1000 nM) increased the expression of ABCA1 and induces cellular cholesterol efflux to apoA1 particles in a dose-dependent manner. In human hepatoma (HepG2) cells, GSK3987 (6-1500 nM) increases the expression of SREBP-1c and induces triglyceride accumulation in a dose-dependent manner. GSK3987 showed activity with EC50s of 0.08 μM, 50 nM, 40 nM for ABCA1, LXRα-SRC1, LXRβ-SRC1, respectively.

RT-PCR Cell Line:HepG2 cells Concentration:6-1500 nM Incubation Time:Result:Increased the expression of SREBP-1c and induced triglyceride accumulation in human hepatoma (HepG2) cells in a dose-dependent manner.

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Others

Other Targets

EP4

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264206-85-1

384.435

C24H20N2O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (260.13 mM)

COc1ccc(NC2=C(C(=O)N(Cc3ccccc3)C2=O)c2ccccc2)cc1

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(-20℃)

With Ice Pack

≥ 2 years