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GSK2850163
CAS No. 2121989-91-9
GSK2850163 ( —— )
产品货号. M26237 CAS No. 2121989-91-9
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥518 | 有现货 |
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| 10MG | ￥915 | 有现货 |
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| 25MG | ￥1936 | 有现货 |
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| 50MG | ￥3062 | 有现货 |
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| 100MG | ￥4601 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GSK2850163
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
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产品描述GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).(In Vitro):The increased autophosphorylation of IRE1α could be reduced in a dose-dependent manner by GSK2850163. Increasing concentrations of GSK2850163 are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163: Ron (IC50: 4.4 μM) and FGFR1 V561M (IC50: 17 μM).
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number2121989-91-9
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分子量446.4
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分子式C24H29Cl2N3O
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纯度>98% (HPLC)
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溶解度——
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SMILESCc1ccc(CNC(=O)N2CCC[C@]3(CCN(Cc4ccc(Cl)c(Cl)c4)C3)C2)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Zhang J, Yong X, Zhao D, Shi Q. Accurate quantification of two key time points used in the determination of hydroxyl polyaluminum species by ferron timed spectrophotometry. J AOAC Int. 2015 Jan-Feb;98(1):225-9. doi: 10.5740/jaoacint.14-073. PMID: 25857902.
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