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GS-143
CAS No. 916232-21-8
GS-143 ( GS 143 | GS143 )
产品货号. M24964 CAS No. 916232-21-8
GS143 是一种选择性 IκBα 泛素化抑制剂，对 SCFβTrCP1 介导的 IκBα 泛素化的 IC50 为 5.2 μM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥437 | 有现货 |
|
| 5MG | ￥721 | 有现货 |
|
| 10MG | ￥1134 | 有现货 |
|
| 25MG | ￥2333 | 有现货 |
|
| 50MG | ￥3686 | 有现货 |
|
| 100MG | ￥5484 | 有现货 |
|
| 500MG | ￥11583 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GS-143
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GS143 是一种选择性 IκBα 泛素化抑制剂，对 SCFβTrCP1 介导的 IκBα 泛素化的 IC50 为 5.2 μM。
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产品描述GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect.
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体外实验——
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体内实验Animal Model:BALB/c mice (age 7-8weeks) injected with oval-bu-min Dosage:16 μg/body or 32 μg/body Administration:Intranasal administration; once Result:Suppressed antigen-induced NF-κB activation in the lung of sensitized mice.
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同义词GS 143 | GS143
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通路Others
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靶点Other Targets
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受体IκBα?phosphorylation
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研究领域——
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适应症——
化学信息
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CAS Number916232-21-8
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分子量466.46
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分子式C28H19FN2O4
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纯度>98% (HPLC)
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溶解度DMSO:40 mg/mL?(85.75 mM;?Need ultrasonic)
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SMILESOC(c(cc1)ccc1N(C1=O)N=C(Cc2ccccc2)C1=Cc1ccc(-c(cccc2)c2F)o1)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Rashmi BS, Gayathri D. Molecular characterization of gluten hydrolysing Bacillus sp. and their efficacy and biotherapeutic potential as probiotics using Caco-2 cell line. J Appl Microbiol. 2017 Sep;123(3):759-772. doi: 10.1111/jam.13517. Epub 2017 Aug 4. PubMed PMID: 28637081.
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