GPNA hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GPNA 盐酸盐是特异性谷氨酰胺 (Gln) 转运蛋白 ASCT2(SLC1A5) 抑制剂。 GPNA 可逆地诱导 A549 细胞凋亡。 GPNA 盐酸盐是 γ-谷氨酰转移酶 (GGT) 的众所周知的底物。

GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2.GPNA (10-1000 μM; 48?hours) induces a dose-dependent to reduce of cell viability in A549 cells.

GPNA (10-1000 μM; 48hours) induces a dose-dependent decrease of cell viability in A549 cells. Cell Viability AssayCell Line:A549 cells Concentration:10, 100, 250, 500 , and 1000 μM Incubation Time:48?hours Result:Induced a dose-dependent decrease of cell viability, with an IC50 roughly corresponding to ~250?μM.

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Others

Other Targets

ASCT2

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67953-08-6

303.70

C11H14ClN3O5

>98% (HPLC)

DMSO:124 mg/mL(408.3 mM)

Cl.N[C@@H](CCC(=O)Nc1ccc(cc1)[N+]([O-])=O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years