GNF2133 ( —— )

产品货号. M28282 CAS No. 2561414-56-8

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HNMR

HPLC

MSDS

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产品名称

GNF2133
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.
产品描述

GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.(In Vitro):GNF2133 has an IC50 of >50 μM for GSK3β. GNF2133 significantly improves glucose disposal capacity and increases insulin secretion.(In Vivo):In Diphtheria toxin A (RIP-DTA) mice, GNF2133 (3, 10, 30 mg/kg) significantly improves glucose disposal capacity and increased insulin secretion. In CD-1 mice, GNF2133 (30 mg/kg; p.o.) shows moderate plasma exposure and good oral absorption with oral bioavailability of 22.3%. In Wistar Han rat, GNF2133 (30 mg/kg; p.o.) increases in cell proliferation marker Ki67 and insulin and reduces cyclin D1 levels and overall cell density.
同义词

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通路

Others
靶点

Other Targets
受体

VEGFR;Tyrosine Kinases
研究领域

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适应症

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1.Yukitsuka Kudo, et al. Benzoxazole derivatives. US7910579B2

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