
GNF2133
CAS No. 2561414-56-8
GNF2133 ( —— )
产品货号. M28282 CAS No. 2561414-56-8
GNF2133 是一种有效的选择性 DYRK1A 抑制剂,IC50 为 6.2 nM。 GNF2133 可用于有关 1 型糖尿病的研究。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥3216 | 有现货 |
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10MG | ¥4771 | 有现货 |
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25MG | ¥7655 | 有现货 |
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50MG | ¥10368 | 有现货 |
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100MG | ¥14013 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称GNF2133
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述GNF2133 是一种有效的选择性 DYRK1A 抑制剂,IC50 为 6.2 nM。 GNF2133 可用于有关 1 型糖尿病的研究。
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产品描述GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.(In Vitro):GNF2133 has an IC50 of >50 μM for GSK3β. GNF2133 significantly improves glucose disposal capacity and increases insulin secretion.(In Vivo):In Diphtheria toxin A (RIP-DTA) mice, GNF2133 (3, 10, 30 mg/kg) significantly improves glucose disposal capacity and increased insulin secretion. In CD-1 mice, GNF2133 (30 mg/kg; p.o.) shows moderate plasma exposure and good oral absorption with oral bioavailability of 22.3%. In Wistar Han rat, GNF2133 (30 mg/kg; p.o.) increases in cell proliferation marker Ki67 and insulin and reduces cyclin D1 levels and overall cell density.
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体外实验——
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体内实验GNF2133 (30 mg/kg; p.o.) shows good oral absorption with oral bioavailability of 22.3%.GNF2133 (30 mg/kg; p.o.; once a day for 5 days) shows the ability to proliferate β-cells in vivo.GNF2133 (3, 10, 30 mg/kg) significantly improves glucose disposal capacity and increased insulin secretion in RIP-DTA mice.Pharmacokinetic Parameters of GNF2133 in CD-1 mice.CD-1 mice; 30 mg/kg; p.o.. Animal Model:CD-1 mice Dosage:30 mg/kg Administration: P.o.Result:Showed good oral absorption and moderate plasma exposure with oral bioavailability of 22.3%.Animal Model:Wistar Han rat Dosage:30 mg/kg (0.5% methylcellulose + Tween-80)Administration:P.o.; once a day for 5 days Result:Increased cyclin D1 levels and overall cell density, and increased in cell proliferation marker Ki67 and insulin.Animal Model:Diphtheria toxin A (RIP-DTA) miceDosage:3, 10, 30 mg/kg (20 mg/kg doxycycline (Dox) for 5 days)Administration:P.o., once a day for 35 daysResult:Significantly improves glucose disposal capacity and increased insulin secretion.
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同义词——
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通路Others
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靶点Other Targets
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受体VEGFR|Tyrosine Kinases
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研究领域——
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适应症——
化学信息
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CAS Number2561414-56-8
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分子量434.53
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分子式C24H30N6O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 4 mg/mL (9.21 mM)
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SMILESO=C(NC1=NC=CC(=C1)C2=CN(C=3C=NC=CC23)C4CCOCC4)N5CCN(CC)CC5
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Yukitsuka Kudo, et al. Benzoxazole derivatives. US7910579B2
产品手册




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