GNF-5837
CAS No. 1033769-28-6
GNF-5837 ( GNF5837; GNF-5837; GNF 5837 )
产品货号. M17764 CAS No. 1033769-28-6
GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥348 | 有现货 |
|
10MG | ¥624 | 有现货 |
|
25MG | ¥1021 | 有现货 |
|
50MG | ¥1604 | 有现货 |
|
100MG | ¥2657 | 有现货 |
|
200MG | ¥3451 | 有现货 |
|
500MG | ¥5605 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称GNF-5837
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).
-
产品描述GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. The properties of GNF-5837 make it a good tool for the elucidation of TRK biology in cancer and other nononcology indications.
-
同义词GNF5837; GNF-5837; GNF 5837
-
通路Others
-
靶点Other Targets
-
受体Kit; PDGFRβ; TrkA; TrkB; TrkC
-
研究领域Cancer
-
适应症——
化学信息
-
CAS Number1033769-28-6
-
分子量535.49
-
分子式C28H21F4N5O2
-
纯度98%
-
溶解度DMSO : ≥ 32 mg/mL; 59.76 mM
-
SMILESCc1c(cc(cc1)NC(=O)Nc1c(ccc(c1)C(F)(F)F)F)Nc1cc2c(cc1)/C(=C/c1ccc[nH]1)/C(=O)N2
-
化学全称(Z)-1-(3-((3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Albaugh P, et al. ACS Med Chem Lett. 2012, 3(2), 140-145.
产品手册
关联产品
-
Methyl nomilinate
Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
-
Iodipamide
A water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.
-
Methyl nomilinate
Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.