GNF-5837 ( GNF5837; GNF-5837; GNF 5837 )

产品货号. M17764 CAS No. 1033769-28-6

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

GNF-5837
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).
产品描述

GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. The properties of GNF-5837 make it a good tool for the elucidation of TRK biology in cancer and other nononcology indications.
同义词

GNF5837; GNF-5837; GNF 5837
通路

Others
靶点

Other Targets
受体

Kit; PDGFRβ; TrkA; TrkB; TrkC
研究领域

Cancer
适应症

——

CAS Number

1033769-28-6
分子量

535.49
分子式

C28H21F4N5O2
纯度

98%
溶解度

DMSO : ≥ 32 mg/mL; 59.76 mM
SMILES

Cc1c(cc(cc1)NC(=O)Nc1c(ccc(c1)C(F)(F)F)F)Nc1cc2c(cc1)/C(=C/c1ccc[nH]1)/C(=O)N2
化学全称

(Z)-1-(3-((3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

1. Albaugh P, et al. ACS Med Chem Lett. 2012, 3(2), 140-145.

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