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GNE-8324
CAS No. 1698901-76-6
GNE-8324 ( —— )
产品货号. M34611 CAS No. 1698901-76-6
GNE-8324 是一种选择性的 GluN2A 阳性变构调节剂。GNE-8324 在抑制性但非兴奋性神经元中选择性增强 NMDA 受体 (NMDAR) 介导的突触反应。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥11886 | 有现货 |
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| 50MG | ￥15484 | 有现货 |
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| 100MG | ￥19125 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GNE-8324
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GNE-8324 是一种选择性的 GluN2A 阳性变构调节剂。GNE-8324 在抑制性但非兴奋性神经元中选择性增强 NMDA 受体 (NMDAR) 介导的突触反应。
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产品描述GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons.
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体外实验A reciprocal allosteric interaction between the GNE-8324 and glutamate binding sites at GluN2A NMDARs such that binding of glutamate enhances binding of GNE-8324 and vice versa. GNE-8324 selectively potentiates GluN2A subunit-containing NMDARs. As a consequence, GNE-8324 potentiation is highly dependent on glutamate site occupancy with enhanced GNE-8324 binding to glutamate-bound NMDARs compared to glutamate-free NMDARs.
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体内实验——
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同义词——
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通路Membrane Transporter/Ion Channel
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靶点NMDAR
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受体NMDAR
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研究领域——
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适应症——
化学信息
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CAS Number1698901-76-6
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分子量343.42
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分子式C18H18FN3OS
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C1C=C(N=C2SC3=C(N12)CCC3)CN(C4=CC=C(F)C=C4)CC
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lulu Yao, et al. Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity. Nat Commun. 2018 Oct 1;9(1):4000.?
