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GNE-1858
CAS No. 2680616-96-8
GNE-1858 ( —— )
产品货号. M26231 CAS No. 2680616-96-8
GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3013 | 有现货 |
|
| 10MG | ￥4504 | 有现货 |
|
| 25MG | ￥7258 | 有现货 |
|
| 50MG | ￥9882 | 有现货 |
|
| 100MG | ￥13365 | 有现货 |
|
| 500MG | ￥26649 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GNE-1858
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).
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产品描述GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).(In Vitro):HPK1 is a negative-feedback regulator of T cell receptor signaling, which dampens T cell proliferation and effector function.Hematopoietic progenitor kinase-1 (HPK1), a serine/threonine Ste20-related protein kinase whose expression is restricted to the hematopoietic compartment (e.g., T cells, B cells, and dendritic cells), is one such kinase.?
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同义词——
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通路Others
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靶点Other Targets
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受体5-HT6
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研究领域——
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适应症——
化学信息
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CAS Number2680616-96-8
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分子量428.5
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分子式C21H26F2N8
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(C)n1ncc2cnc(Nc3cc(nc(n3)N3CCC(F)(F)C3)C3CCNC3)cc12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Tse S, Leung L, Raje S, Seymour M, Shishikura Y, Obach RS. Disposition and metabolic profiling of [(14)C]cerlapirdine using accelerator mass spectrometry. Drug Metab Dispos. 2014 Dec;42(12):2023-32.
产品手册
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