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GNE-131
CAS No. 1629063-81-5
GNE-131 ( —— )
产品货号. M23727 CAS No. 1629063-81-5
GNE-131 是一种有效且特异性的人钠通道 NaV1.7 抑制剂 (IC50: 3 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3013 | 有现货 |
|
| 10MG | ￥4350 | 有现货 |
|
| 25MG | ￥7039 | 有现货 |
|
| 50MG | ￥9639 | 有现货 |
|
| 100MG | ￥12879 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GNE-131
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GNE-131 是一种有效且特异性的人钠通道 NaV1.7 抑制剂 (IC50: 3 nM)。
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产品描述GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
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体外实验GNE-131 (Compound 13) shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 with an IC50 of 0.003±0.001 μM. GNE-131 shows excellent potency, good in vitro metabolic stability.
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体内实验GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain.
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同义词——
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通路Membrane Transporter/Ion Channel
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靶点Sodium Channel
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受体Nav1.7 channel
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研究领域——
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适应症——
化学信息
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CAS Number1629063-81-5
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分子量442.57
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分子式C23H30N4O3S
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纯度>98% (HPLC)
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溶解度DMSO:120 mg/mL (271.14 mM; Need ultrasonic)
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SMILESO=S(C1CC1)(NC2=NN=C3C=C(OCC45CC6CC(C5)CC(C6)C4)C(C7CC7)=CN32)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Focken T, et al. Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. J Med Chem. 2018 Jun 14;61(11):4810-4831.
产品手册
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