GDC-0623 ( GDC0623; GDC-0632; GDC 0632; G868; G 868; G-868 )

产品货号. M17163 CAS No. 1168091-68-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

GDC-0623
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
产品描述

GDC-0623, also known as G-868, is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
同义词

GDC0623; GDC-0632; GDC 0632; G868; G 868; G-868
通路

Others
靶点

Other Targets
受体

MEK1
研究领域

Cancer
适应症

——

CAS Number

1168091-68-6
分子量

456.21
分子式

C16H14FIN4O3
纯度

98%
溶解度

DMSO : ≥ 30 mg/mL. 65.76 mM
SMILES

OCCONC(=O)C1=C(NC2=C(F)C=C(I)C=C2)N2C=NC=C2C=C1
化学全称

5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide

计算器

产品手册

关联产品

Alternariol-trimethy...

The media of Alternaria alternata strain 261.
Methyl nomilinate

Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
Nardosinonediol

Nardosinonediol shows cytotoxic activity against P-388 cells.