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GBT-440
CAS No. 1446321-46-5
GBT-440 ( GBT 440;GBT440;Voxelotor )
产品货号. M11895 CAS No. 1446321-46-5
A new potent allosteric effector of sickle cell hemoglobin; increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥413 | 有现货 |
|
| 10MG | ￥599 | 有现货 |
|
| 25MG | ￥988 | 有现货 |
|
| 50MG | ￥1604 | 有现货 |
|
| 100MG | ￥2989 | 有现货 |
|
| 200MG | ￥4447 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GBT-440
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A new potent allosteric effector of sickle cell hemoglobin; increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions.
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产品描述A new potent allosteric effector of sickle cell hemoglobin; increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions; orally bioavailable and partitions highly and favorably into the red blood cell with a RBC/plasma ratio of ～150.Anemia Phase 3 Clinical
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同义词GBT 440;GBT440;Voxelotor
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Other Indications
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适应症Anemia
化学信息
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CAS Number1446321-46-5
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分子量337.37
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分子式C19H19N3O3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=CC1=C(OCC2=CC=CN=C2C3=CC=NN3C(C)C)C=CC=C1O
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化学全称Benzaldehyde, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Metcalf B, et al. ACS Med Chem Lett. 2017 Jan 23;8(3):321-326.
2. Oksenberg D, et al. Br J Haematol. 2016 Oct;175(1):141-53.
3. Dufu K, et al. Hematol Rep. 2016 Sep 28;8(3):6637.
2. Oksenberg D, et al. Br J Haematol. 2016 Oct;175(1):141-53.
3. Dufu K, et al. Hematol Rep. 2016 Sep 28;8(3):6637.
产品手册
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