Furaprofen

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Furaprofen (R803) 是一种有效的 HCV 复制抑制剂。作用于 HCV 基因型 1a 和 1b 复制子时 EC50 约为 30 nM，作用于基因型 2a 复制子时 EC50 约为 1000 nM。

Furaprofen (R803) is an effective HCV replication inhibitor. Furaprofen (R803) is substantially more potent against genotype 1a and 1b replicons (EC50, ~30 nM) than against the genotype 2a replicon (EC50, ~1,000 nM).

Furaprofen (R803) is potent and highly specific for HCV replication. The antiviral activity of Furaprofen has been determined by a reporter replicon assay with multiple repeats to be 29.88±8.05 nM, an ~3-fold improvement over the activity of the parent compound, R706. The potency of Furaprofen against the replicon is also confirmed by both Western blotting and TaqMan RT-PCR to be about 37 nM and 54.67±4.11 nM, respectively. To assess the general effect of Furaprofen on cell proliferation, a panel of primary cells and transformed human cell lines are treated with increasing doses of Furaprofen for 48 h, and the effect on cell proliferation is measured by an MTS-based cell viability assay. The the concentration that caused a 50% reduction in cell numbers in the absence of virus infection (CC50)of Furaprofen is found to range from 2 μM to ≥10 μM, depending on the cell type and proliferation status.

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Others

Other Targets

HCV Protease

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67700-30-5

266.29

C17H14O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (938.83 mM; 超声助溶 )

CC(C(O)=O)c1cccc2c(coc12)-c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years