Furafylline

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Furafylline 是人细胞色素 P450 (CYP)1A2 的选择性抑制剂 (IC50 : 0.07 μM)，

Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 μM)

——

Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA.

——

Metabolic Enzyme/Protease

P450

CYP450

——

——

80288-49-9

260.25

C12H12N4O3

>98% (HPLC)

DMSO:12.5 mg/mL (48.03 mM)

Cc1nc2n(Cc3ccco3)c(=O)n(C)c(=O)c2[nH]1

——

(-20℃)

With Ice Pack

≥ 2 years