
Filorexant
CAS No. 1088991-73-4
Filorexant ( MK-6096 )
产品货号. M26757 CAS No. 1088991-73-4
Filorexant 是一种口服生物可利用的有效且选择性可逆的 OX1 和 OX2 受体拮抗剂(Ki <3 nM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥713 | 有现货 |
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5MG | ¥1191 | 有现货 |
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10MG | ¥2001 | 有现货 |
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25MG | ¥3467 | 有现货 |
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50MG | ¥5127 | 有现货 |
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100MG | ¥7152 | 有现货 |
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200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Filorexant
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Filorexant 是一种口服生物可利用的有效且选择性可逆的 OX1 和 OX2 受体拮抗剂(Ki <3 nM)。
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产品描述Filorexant is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).(In Vitro):Filorexant occupies 90% of human OX(2)Rs expressed in transgenic rats at a plasma concentration of 142 nM. Filorexant demonstrated effective binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), in radioligand binding and functional cell-based assays. It has no significant off-target activities against a panel of >170 receptors and enzymes .(In Vivo):Filorexant dose-dependently decreased locomotor activity and obviously enhanced sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg).
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体外实验In radioligand binding and functional cell based assays Filorexant (MK-6096) demonstrated potent binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), with no significant off-target activities against a panel of >170 receptors and enzymes. Filorexant (MK-6096) occupies 90% of human OX(2)Rs expressed in transgenic rats at a plasma concentration of 142 nM.
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体内实验Filorexant (MK-6096) dose-dependently reduced locomotor activity and significantly increased sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg).
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同义词MK-6096
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number1088991-73-4
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分子量420.488
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分子式C24H25FN4O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (237.82 mM)
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SMILESC[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ncccn1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Maria Cristina Silva Louren?o, et al.Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents, Bioorganic & Medicinal Chemistry Letters, Volume 17, Issue 24, 2007, Pages 6895-6898.
产品手册




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