Filorexant
CAS No. 1088991-73-4
Filorexant ( MK-6096 )
产品货号. M26757 CAS No. 1088991-73-4
Filorexant is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥713 | 有现货 |
|
5MG | ¥1191 | 有现货 |
|
10MG | ¥2001 | 有现货 |
|
25MG | ¥3467 | 有现货 |
|
50MG | ¥5127 | 有现货 |
|
100MG | ¥7152 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Filorexant
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Filorexant is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).
-
产品描述Filorexant is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).(In Vitro):Filorexant occupies 90% of human OX(2)Rs expressed in transgenic rats at a plasma concentration of 142 nM. Filorexant demonstrated effective binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), in radioligand binding and functional cell-based assays. It has no significant off-target activities against a panel of >170 receptors and enzymes .(In Vivo):Filorexant dose-dependently decreased locomotor activity and obviously enhanced sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg).
-
同义词MK-6096
-
通路Others
-
靶点Other Targets
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number1088991-73-4
-
分子量420.5
-
分子式C24H25FN4O2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESC[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ncccn1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Maria Cristina Silva Louren?o, et al.Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents, Bioorganic & Medicinal Chemistry Letters, Volume 17, Issue 24, 2007, Pages 6895-6898.
产品手册
关联产品
-
6-Acetyl-2,2-dimethy...
6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
-
Methyl nomilinate
Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
-
Sophocarpine monohyd...
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.