FTBMT

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FTBMT 是一种选择性 GPR52 激动剂 (EC50: 75 nM)，还具有抗精神病和促认知特性。

FTBMT is a selective GPR52 agonist (EC50: 75 nM) and it also has antipsychotic and procognitive properties.(In Vitro):In CHO cells expressing human, mouse, or rat GPR52, FTBMT (0.1-10 μM) improves intracellular cAMP levels (pEC50s of 7.03, 6.85, and 6.87, respectively).(In Vivo):In rats, FTBMT (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory. FTBMT (30 mg/kg, 90 minutes) shows antipsychotic-like activity without causing catalepsy in mice

TP-024 (FTBMT) (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50s of 7.03, 6.85, and 6.87, respectively. Cell Viability Assay Cell Line:CHO cells (expressing GPR52 receptors) cAMP assay Concentration:0.1-10 μM Incubation Time: 30 minutes Result:FTBMT activated cAMP signaling in vitro.

TP-024 (FTBMT) (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice.TP-024 (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats.TP-024 (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition. Animal Model:Male Long-Evans rats (9 weeks old) Dosage:10 mg/kg Administration:Oral, 1 hour before memory test Result:A 1-hour pretreatment with FTBMT (10 mg/kg, p.o.) significantly decreases the number of memory errors induced by MK-801.Animal Model:Male ICR mice (7 to 8 weeks old) Dosage:3–30 mg/kg Administration:Oral, 60 minutes before s.c. administration of MK-801 Result:FTBMT increases phospho-DARPP32 levels in the NAc slices.

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Cell Cycle/DNA Damage

GPR

Estrogen Receptor/ERR| Human Endogenous Metabolite

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1358575-02-6

392.358

C19H16F4N4O

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (127.44 mM)

Cc1nc(Cc2cc(F)cc(c2)C(F)(F)F)nn1-c1ccc(C(N)=O)c(C)c1

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(-20℃)

With Ice Pack

≥ 2 years