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FM19G11

CAS No. 329932-55-0

FM19G11 ( HIF-1alpha/2alpha Inhibitor )

产品货号. M28084 CAS No. 329932-55-0

Hypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥786 有现货
10MG ¥1442 有现货
25MG ¥3216 有现货
50MG ¥4771 有现货
100MG ¥6828 有现货
500MG ¥14013 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    FM19G11
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Hypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms.
  • 产品描述
    Hypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O6-methylguanine DNA methyltransferase (MGMT) via HIF1α pathway, under normal and hypoxic conditions in glioblastoma cell lines.(In Vitro):FM19G11 (500 nM) promotes oligodendrocyte differentiation under hypoxic conditions. FM19G11 (300 nM) significantly enhances the pro-apoptotic effect of temozolomide, whereas FM19G11 does not induce apoptosis. In hypoxic GBM-XD, hypoxic T98G, and normoxic T98G cells, FM19G11 (300 nM) significantly inhibited the mRNA level of O6-methylguanine DNA-methyltransferase via the HIF-1α pathway.(In Vivo):Intramedullary injection of FM19G11 improves locomotion in severe spinal cord injury and induces the expression of GAP43 and RIP at the injury.
  • 同义词
    HIF-1alpha/2alpha Inhibitor
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    5-HT1B;5-HT1D
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    329932-55-0
  • 分子量
    463.4
  • 分子式
    C23H17N3O8
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    Cc1ccc(cc1)C(=O)COC(=O)c1cccc(NC(=O)c2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)c1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Mu?oz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149(1):82-91.
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