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FIIN-2
CAS No. 1633044-56-0
FIIN-2 ( FIIN2; FIIN 2; FIIN-2 )
产品货号. M17351 CAS No. 1633044-56-0
FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥389 | 有现货 |
|
| 5MG | ￥713 | 有现货 |
|
| 10MG | ￥1272 | 有现货 |
|
| 25MG | ￥2471 | 有现货 |
|
| 50MG | ￥4431 | 有现货 |
|
| 100MG | ￥6310 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称FIIN-2
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.
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产品描述FIIN-2 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-2 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-2 also binds in the DFG-out mode despite lacking a functional group necessary to occupy the pocket vacated upon the DFG-out flip.
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同义词FIIN2; FIIN 2; FIIN-2
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通路GPCR/G Protein
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靶点Dopamine Receptor
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受体FGFR1; FGFR2; FGFR3; FGFR4
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研究领域Cancer
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适应症——
化学信息
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CAS Number1633044-56-0
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分子量634.73
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分子式C35H38N8O4
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纯度98%
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溶解度DMSO : ≥ 30 mg/mL 47.26 mM
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SMILESCN1CCN(CC1)c1ccc(cc1)Nc1ncc2CN(C(=O)N(c2n1)Cc1ccc(cc1)NC(=O)C=C)c1cc(cc(c1)OC)OC
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化学全称N-(4-((3-(3,5-dimethoxyphenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Tan L, et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-4877.
产品手册
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