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Etomoxir
CAS No. 124083-20-1
Etomoxir ( Etomoxir; B 807-54;B80754; B-80754; (R)-(+)-Etomoxir )
产品货号. M10974 CAS No. 124083-20-1
An irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) that inhibits fatty acid β-oxidation in rat liver with IC50 of 5-20 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥543 | 有现货 |
|
| 10MG | ￥948 | 有现货 |
|
| 25MG | ￥1847 | 有现货 |
|
| 50MG | ￥3378 | 有现货 |
|
| 100MG | ￥5014 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Etomoxir
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述An irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) that inhibits fatty acid β-oxidation in rat liver with IC50 of 5-20 nM.
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产品描述An irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) that inhibits fatty acid β-oxidation in rat liver with IC50 of 5-20 nM; affects ketogenesis, cholesterol synthesis, and gluconeogenesis both in vitro and in vivo; decreases viability in LNCaP, VCaP, and patient-derived benign and prostate cancer cells, associated with decreased AR expression, decreased mTOR signaling, and increased caspase-3 activation; decreases xenograft growth in mice.Heart Failure Phase 2 Discontinued
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同义词Etomoxir; B 807-54;B80754; B-80754; (R)-(+)-Etomoxir
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Metabolic Disease
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适应症——
化学信息
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CAS Number124083-20-1
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分子量326.82
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分子式C17H23ClO4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C([C@]1(CCCCCCOC2=CC=C(Cl)C=C2)OC1)OCC
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化学全称2-Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lopaschuk GD, et al. Circ Res. 1988 Dec;63(6):1036-43.
2. Kruszynska YT, et al. Biochem Pharmacol. 1987 Nov 15;36(22):3917-21.
3. Schlaepfer IR, et al. Mol Cancer Ther. 2014 Oct;13(10):2361-71.
2. Kruszynska YT, et al. Biochem Pharmacol. 1987 Nov 15;36(22):3917-21.
3. Schlaepfer IR, et al. Mol Cancer Ther. 2014 Oct;13(10):2361-71.
产品手册
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