Eplerenone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

依普利酮是一种类似于螺内酯的醛固酮受体拮抗剂，已被证明可以使血浆肾素和血清醛固酮持续增加。

Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors. (In Vitro):Eplerenone inhibits the human mineralocorticoid receptor with IC50 value of 0.081 μM.(In Vivo):Eplerenone (oral, 200 mg/kg/day for 3 months) significantly reduces oxidative stress and atherosclerosis progression in atherosclerotic apolipoprotein edeficient (EO) mice.

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CGP 30083 | (+)-Eplerenone | Epoxymexrenone | SC-6110 | SC-66110

Endocrinology/Hormones

GR

Mineralocorticoid Receptor

Cardiovascular Disease

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107724-20-9

414.49

C24H30O6

>98% (HPLC)

Ethanol: <1 mg/mL (<1 mM); Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)

C[C@]12CCC(C=C1C[C@@H](C(OC)=O)[C@@H]3[C@]24[C@@H](C[C@@]5(C)[C@H]3CC[C@@]56CCC(O6)=O)O4)=O

methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate

(-20℃)

With Ice Pack

≥ 2 years