
Eniluracil
CAS No. 59989-18-3
Eniluracil ( 5-Ethynyluracil | GW776C85 )
产品货号. M20971 CAS No. 59989-18-3
Eniluracil 是一种口服活性二氢嘧啶脱氢酶 (DPD) 抑制剂,可将 5-FU 的口服生物利用度提高至 100%,促进均匀吸收和可预测的毒性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
10MG | ¥332 | 有现货 |
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25MG | ¥616 | 有现货 |
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50MG | ¥1004 | 有现货 |
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100MG | ¥1499 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Eniluracil
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Eniluracil 是一种口服活性二氢嘧啶脱氢酶 (DPD) 抑制剂,可将 5-FU 的口服生物利用度提高至 100%,促进均匀吸收和可预测的毒性。
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产品描述Eniluracil is an orally activedihydropyrimidine dehydrogenase (DPD) inhibitorincreases the oral bioavailability of 5-FU to 100% facilitating uniform absorption and predictable toxicity.(In Vivo):Eniluracil (5-Ethynyluracil) (1 mg/kg; i.p.; single daily for 3 days) exhibits neither toxicity nor intrinsic antitumor activity, and greatly improves FUra (5-fluorouracil) therapy in rats.
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体外实验——
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体内实验Eniluracil (5-Ethynyluracil) (1 mg/kg; i.p.; single daily for 3 days) exhibits neither toxicity nor intrinsic antitumor activity, and greatly improves FUra (5-fluorouracil) therapy in rats. Animal Model:Female Fischer 344/HSD rats (6 to 7-week-old; 150-200 g).Dosage:1 mg/kg Administration:Intraperitoneal injection; single daily for 3 days (l h before FUra (5-fluorouracil) and for an additional 2 days after FUra therapy)Result:Produced complete tumor regression that was sustained for at least 90 days posttherapy when combined with 3.5 mg/kg FUra, however, 35 mg/kg FUra alone produced partial responses in 75% of the treated animals ( the tumors regrew in all of these animals).
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同义词5-Ethynyluracil | GW776C85
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通路Others
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靶点Other Targets
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受体dihydropyrimidine dehydrogenase (DPD)
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研究领域Cancer
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适应症Colorectal Cancer; Erythrodysaesthesia; Head and neck Cancer; Liver Cancer; Pancreatic Cancer; Prostate Cancer; Solid tumours
化学信息
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CAS Number59989-18-3
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分子量136.11
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分子式C6H4N2O2
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纯度>98% (HPLC)
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溶解度DMSO:62.5 mg/mL (459.19 mM)
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SMILESC#Cc1c[nH]c(=O)[nH]c1=O
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化学全称5-ethynylpyrimidine-24(1H3H)-dione.
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Kindler H L Schilsky R L . Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase[J]. Expert Opinion on Investigational Drugs 2000 9(7):1635-1649.