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Eniluracil

CAS No. 59989-18-3

Eniluracil ( 5-Ethynyluracil | GW776C85 )

产品货号. M20971 CAS No. 59989-18-3

Eniluracil 是一种口服活性二氢嘧啶脱氢酶 (DPD) 抑制剂,可将 5-FU 的口服生物利用度提高至 100%,促进均匀吸收和可预测的毒性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
10MG ¥332 有现货
25MG ¥616 有现货
50MG ¥1004 有现货
100MG ¥1499 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Eniluracil
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Eniluracil 是一种口服活性二氢嘧啶脱氢酶 (DPD) 抑制剂,可将 5-FU 的口服生物利用度提高至 100%,促进均匀吸收和可预测的毒性。
  • 产品描述
    Eniluracil is an orally activedihydropyrimidine dehydrogenase (DPD) inhibitorincreases the oral bioavailability of 5-FU to 100% facilitating uniform absorption and predictable toxicity.(In Vivo):Eniluracil (5-Ethynyluracil) (1 mg/kg; i.p.; single daily for 3 days) exhibits neither toxicity nor intrinsic antitumor activity, and greatly improves FUra (5-fluorouracil) therapy in rats.
  • 体外实验
    ——
  • 体内实验
    Eniluracil (5-Ethynyluracil) (1 mg/kg; i.p.; single daily for 3 days) exhibits neither toxicity nor intrinsic antitumor activity, and greatly improves FUra (5-fluorouracil) therapy in rats. Animal Model:Female Fischer 344/HSD rats (6 to 7-week-old; 150-200 g).Dosage:1 mg/kg Administration:Intraperitoneal injection; single daily for 3 days (l h before FUra (5-fluorouracil) and for an additional 2 days after FUra therapy)Result:Produced complete tumor regression that was sustained for at least 90 days posttherapy when combined with 3.5 mg/kg FUra, however, 35 mg/kg FUra alone produced partial responses in 75% of the treated animals ( the tumors regrew in all of these animals).
  • 同义词
    5-Ethynyluracil | GW776C85
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    dihydropyrimidine dehydrogenase (DPD)
  • 研究领域
    Cancer
  • 适应症
    Colorectal Cancer; Erythrodysaesthesia; Head and neck Cancer; Liver Cancer; Pancreatic Cancer; Prostate Cancer; Solid tumours

化学信息

  • CAS Number
    59989-18-3
  • 分子量
    136.11
  • 分子式
    C6H4N2O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:62.5 mg/mL (459.19 mM)
  • SMILES
    C#Cc1c[nH]c(=O)[nH]c1=O
  • 化学全称
    5-ethynylpyrimidine-24(1H3H)-dione.

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Kindler H L Schilsky R L . Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase[J]. Expert Opinion on Investigational Drugs 2000 9(7):1635-1649.
产品手册
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