Engeletin ( —— )

产品货号. M18834 CAS No. 572-31-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Engeletin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Engeletin 具有有效抑制 PGE2 释放的作用，IC5 值为 19.6 μg/ml。
产品描述

Engeletin may serve as a potential anti-inflammatory agent. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engeletin inhibits a recombinant human aldose reductase (IC5 value=1.16 microM).
体外实验

Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation.
体内实验

Engeletin (25, 50, 100 mg/kg, i.p.) markedly reduces LPS-increased myeloperoxidase activity in mice, activates NF-κB-pathway activation, decreases the production of inflammatory mediators (iNOS and COX-2), and suppresses the expression of TLR4-signaling downstream molecules such as MyD88, IRAK1, TRAF6, and TAK1 proteins.
同义词

——
通路

Others
靶点

Other Targets
受体

Aldose reductase
研究领域

Inflammation/Immunology
适应症

——

计算器

产品手册

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