Emodin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

大黄素是一种天然存在的蒽醌，存在于许多植物的根和树皮中；在受不同信号通路调节的 Y 细胞中发挥抗增殖作用。

Emodin is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells that are regulated by different signaling pathways.

Cell Viability Assay Cell Line:Vero E6 cells transfected with the plasmid encoding ACE2 Concentration:0, 5, 25, 50 μM Incubation Time:24 hours Result:Vero cells treated with 50 μM remained 82.4±3.8% viability, the anti-SARS-CoV activity was not due to toxicity.

Animal Model:C57BL/6J male mice Dosage:100 or 200 mg/kg Administration:Acute administered p.o. ; Two hours later, the mice were killed by cervical dislocation,Result:Significantly inhibited liver 11β-HSD1 enzymatic activity by 17.6 and 31.3% and mesenteric fat 11β-HSD1 enzymatic activity by 21.5 and 46.7% at 100 or 200 mg/kg, respectively. Animal Model:DIO mice (C57BL/6J male mice were fed a formulated research diet)Dosage:100 mg/kg Administration:Oral gavage; twice per day; for 35 days Result:Reduced fasting glucose concentrations to 77.2% of the vehicle control mice after 7 days of treatment, and these remained significantly lower throughout the treatment period. Exhibited a significant reduction in blood glucose levels at all time-points following oral glucose challenge after 24 days of treatment. Evoked a significantly greater reduction in blood glucose values 40 and 90 min after insulin injection after 28 days of treatment. The serum insulin level was also significantly reduced, to 66.2% of control mice, after 35 days of treatment. Improved the lipid profiles. The serum triglyceride and total cholesterol levels were significantly reduced by 19.3 and 12.5% after 35 days of treatment, respectively. Caused a 22.7% reduction of non-esterified free fatty acid (NEFA) level. Lowered body weight and appetite from day 18 of the treatment; their body weights were reduced by 13.9% at the end of treatment.

Archin | Frangulic Acid | NSC 408120 | NSC 622947 | Schuttgelb

Metabolic Enzyme/Protease

Casein Kinase

CK2

Cancer

——

518-82-1

270.24

C15H10O5

>98% (HPLC)

Ethanol: 3 mg/mL (11.1 mM); DMSO: 54 mg/mL (199.82 mM)

O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O)=CC(O)=C13)=O

1,3,8-trihydroxy-6-methylanthracene-9,10-dione

(-20℃)

With Ice Pack

≥ 2 years