
Emapunil
CAS No. 226954-04-7
Emapunil ( AC-5216 | XBD-173 )
产品货号. M17446 CAS No. 226954-04-7
Emapunil 是一种抗焦虑化合物,作为外周苯二氮卓受体(也称为线粒体 18 kDa 易位蛋白或 TSPO)的选择性激动剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥437 | 有现货 |
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5MG | ¥786 | 有现货 |
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10MG | ¥1191 | 有现货 |
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25MG | ¥2228 | 有现货 |
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50MG | ¥4415 | 有现货 |
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100MG | ¥6359 | 有现货 |
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500MG | ¥13203 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Emapunil
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Emapunil 是一种抗焦虑化合物,作为外周苯二氮卓受体(也称为线粒体 18 kDa 易位蛋白或 TSPO)的选择性激动剂。
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产品描述Emapunil is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO.(In Vivo):Emapunil (AC-5216, 0.1-3, 0.003-0.01 and 0.01-0.3 mg/kg, p.o.) produces anti-anxiety effects in the Vogel-type conflict test in rats, and in the light/dark box and social interaction tests in mice.Emapunil (AC-5216, 3-30 mg/kg, p.o.) reduces the immobility time, and this effect was blocked by PK11195.Emapunil (AC-5216, 1-100 mg/kg, p.o.) produces no distinct change in the rat electroencephalogram.Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) causes significant suppression of the enhanced anxiety and contextual fear induced in post-TDS rats.Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) alleviates the enhanced anxiety and fear response in a time-dependent sensitization (TDS) procedure, a rat PTSD animal model.Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) reverses the increased plasma glucose (PG) and decreased insulin (INS) in HFD-STZ rats.
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体外实验——
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体内实验Animal Model:Rats.Dosage:0.1-3 mg/kg.Administration:P.O.. Result:Significantly increased the number of shocks that rats received.Significantly increased the time spent in the light compartment but only slightly increased that time at 0.03 mg/kg, p.o. (P<0.1).
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同义词AC-5216 | XBD-173
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通路Others
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靶点Other Targets
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受体TSPO ligand
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number226954-04-7
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分子量401.46
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分子式C23H23N5O2
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纯度>98% (HPLC)
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溶解度DMSO : 33.33 mg/mL 83.02 mM;
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SMILESCCN(Cc1ccccc1)C(=O)Cn1c2nc(ncc2n(c1=O)C)c1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Rupprecht R, et al. Science. 2009 Jul 24;325(5939):490-3.
产品手册




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