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Emapunil

CAS No. 226954-04-7

Emapunil ( AC-5216 | XBD-173 )

产品货号. M17446 CAS No. 226954-04-7

Emapunil 是一种抗焦虑化合物,作为外周苯二氮卓受体(也称为线粒体 18 kDa 易位蛋白或 TSPO)的选择性激动剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥437 有现货
5MG ¥786 有现货
10MG ¥1191 有现货
25MG ¥2228 有现货
50MG ¥4415 有现货
100MG ¥6359 有现货
500MG ¥13203 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Emapunil
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Emapunil 是一种抗焦虑化合物,作为外周苯二氮卓受体(也称为线粒体 18 kDa 易位蛋白或 TSPO)的选择性激动剂。
  • 产品描述
    Emapunil is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO.(In Vivo):Emapunil (AC-5216, 0.1-3, 0.003-0.01 and 0.01-0.3 mg/kg, p.o.) produces anti-anxiety effects in the Vogel-type conflict test in rats, and in the light/dark box and social interaction tests in mice.Emapunil (AC-5216, 3-30 mg/kg, p.o.) reduces the immobility time, and this effect was blocked by PK11195.Emapunil (AC-5216, 1-100 mg/kg, p.o.) produces no distinct change in the rat electroencephalogram.Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) causes significant suppression of the enhanced anxiety and contextual fear induced in post-TDS rats.Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) alleviates the enhanced anxiety and fear response in a time-dependent sensitization (TDS) procedure, a rat PTSD animal model.Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) reverses the increased plasma glucose (PG) and decreased insulin (INS) in HFD-STZ rats.
  • 体外实验
    ——
  • 体内实验
    Animal Model:Rats.Dosage:0.1-3 mg/kg.Administration:P.O.. Result:Significantly increased the number of shocks that rats received.Significantly increased the time spent in the light compartment but only slightly increased that time at 0.03 mg/kg, p.o. (P<0.1).
  • 同义词
    AC-5216 | XBD-173
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    TSPO ligand
  • 研究领域
    Neurological Disease
  • 适应症
    ——

化学信息

  • CAS Number
    226954-04-7
  • 分子量
    401.46
  • 分子式
    C23H23N5O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : 33.33 mg/mL 83.02 mM;
  • SMILES
    CCN(Cc1ccccc1)C(=O)Cn1c2nc(ncc2n(c1=O)C)c1ccccc1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Rupprecht R, et al. Science. 2009 Jul 24;325(5939):490-3.
产品手册
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