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ERCC1-XPF-IN-2
CAS No. 1808986-37-9
ERCC1-XPF-IN-2 ( —— )
产品货号. M35487 CAS No. 1808986-37-9
ERCC1-XPF-IN-2 是一种有效的 ERCC1-XPF 核酸内切酶抑制剂，IC50 值为 0.6 μM。ERCC1-XPF-IN-2 在核苷酸切除修复、顺铂增强和 γH2AX 测定中显示出活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥444 | 有现货 |
|
| 10MG | ￥783 | 有现货 |
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| 25MG | ￥1541 | 有现货 |
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| 50MG | ￥2565 | 有现货 |
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| 100MG | ￥3802 | 有现货 |
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| 200MG | ￥5301 | 有现货 |
|
| 500MG | ￥8262 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ERCC1-XPF-IN-2
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ERCC1-XPF-IN-2 是一种有效的 ERCC1-XPF 核酸内切酶抑制剂，IC50 值为 0.6 μM。ERCC1-XPF-IN-2 在核苷酸切除修复、顺铂增强和 γH2AX 测定中显示出活性。
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产品描述ERCC1-XPF-IN-2 is a potent ERCC1-XPF endonuclease inhibitor with an IC50 value of 0.6 μM. ERCC1-XPF-IN-2 shows activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays.
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体外实验ERCC1-XPF-IN-2 (compound 13) (0-100 μM) shows FEN-1 and DNase I activity with IC50s of >100, >100 μM, respectively.ERCC1-XPF-IN-2 slow binding kinetics with an Kd value of ~30 μM.ERCC1-XPF-IN-2 shows not toxic to Hep-G2 cells at 10 μM and relatively short mouse and human microsomal half-lives with t1/2 value of 23 min and 28 min for mouse and human, respectively.ERCC1-XPF-IN-2 (0-60 μM; 24 h) shows inhibition of nucleotide excision repair (NER) with an IC50 value of 15.6 μM in A375 cells.ERCC1-XPF-IN-2 (0-60 μM) increases the cisplatin activity with no toxicity.ERCC1-XPF-IN-2 (10 μM; 6h) causes a delay in DNA repair by a right shift towards higher numbers of γH2AX foci per cell.Cell Cytotoxicity Assay Cell Line:A375 cells Concentration:0-60 μM Incubation Time: Result: Showed no toxicity and increased the cisplatin activity up to 1.5-fold (PF50).
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number1808986-37-9
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分子量326.17
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分子式C15H13Cl2NO3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : ≥ 250 mg/mL (766.47 mM; )
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SMILESOc1ccc(CNC(=O)Cc2ccc(Cl)cc2Cl)cc1O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Chapman TM, et al. Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4097-103.?
