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ER-000444793
CAS No. 792957-74-5
ER-000444793 ( —— )
产品货号. M24791 CAS No. 792957-74-5
ER-000444793 是一种有效的线粒体通透性转换孔 (mPTP) 打开抑制剂，它还能抑制 mPTP (IC50: 2.8 μM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1320 | 有现货 |
|
| 10MG | ￥2001 | 有现货 |
|
| 25MG | ￥3969 | 有现货 |
|
| 50MG | ￥5792 | 有现货 |
|
| 100MG | ￥7995 | 有现货 |
|
| 500MG | ￥16038 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ER-000444793
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ER-000444793 是一种有效的线粒体通透性转换孔 (mPTP) 打开抑制剂，它还能抑制 mPTP (IC50: 2.8 μM)。
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产品描述ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8?μM).
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体外实验ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. ER-000444793 potently and dose-dependently inhibits Ca2+-induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC50=23?nM and SfA IC50=?5?nM). In contrast, ER-000444793 has no effect up to a concentration of 50?μM, indicating lack of displacement of labelled-CsA from rhCypD protein. Together, these data suggest the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体mPTP
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研究领域——
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适应症——
化学信息
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CAS Number792957-74-5
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分子量354.4
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分子式C23H18N2O2
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纯度>98% (HPLC)
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溶解度DMSO:50 mg/mL (141.08 mM; Need ultrasonic)
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SMILESO=C(NC1=C(CC2=CC=CC=C2)C=CC=C1)C(C3=CC=CC=C3N4)=CC4=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Briston T, et al. Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria. Sci Rep. 2016 Nov 25;6:37798.
产品手册
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