ER-000444793 ( —— )

产品货号. M24791 CAS No. 792957-74-5

ER-000444793 是一种有效的线粒体通透性转换孔 (mPTP) 打开抑制剂，它还能抑制 mPTP (IC50: 2.8 μM)。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥1320	有现货
10MG	￥2001	有现货
25MG	￥3969	有现货
50MG	￥5792	有现货
100MG	￥7995	有现货
500MG	￥16038	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

ER-000444793
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ER-000444793 是一种有效的线粒体通透性转换孔 (mPTP) 打开抑制剂，它还能抑制 mPTP (IC50: 2.8 μM)。
产品描述

ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8?μM).
体外实验

ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. ER-000444793 potently and dose-dependently inhibits Ca2+-induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC50=23?nM and SfA IC50=?5?nM). In contrast, ER-000444793 has no effect up to a concentration of 50?μM, indicating lack of displacement of labelled-CsA from rhCypD protein. Together, these data suggest the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

mPTP
研究领域

——
适应症

——

化学信息

CAS Number

792957-74-5
分子量

354.4
分子式

C23H18N2O2
纯度

>98% (HPLC)
溶解度

DMSO:50 mg/mL (141.08 mM; Need ultrasonic)
SMILES

O=C(NC1=C(CC2=CC=CC=C2)C=CC=C1)C(C3=CC=CC=C3N4)=CC4=O
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Briston T, et al. Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria. Sci Rep. 2016 Nov 25;6:37798.

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