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E67-2
CAS No. 1364914-62-4
E67-2 ( —— )
产品货号. M11507 CAS No. 1364914-62-4
E67-2 是 H3K9 Jumonji 去甲基化酶 KIAA1718 (KDM7A) 的有效选择性抑制剂，IC50 为 3.4 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称E67-2
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述E67-2 是 H3K9 Jumonji 去甲基化酶 KIAA1718 (KDM7A) 的有效选择性抑制剂，IC50 为 3.4 uM。
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产品描述E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM; selectively inhibits H3K9 Jumonji demethylase over H3K9 methyltransferase as well as H3K4 demethylase, has low cytotoxicity.
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体外实验E67-2 (1~100 μM; 5 minutes) reduces inhibitory effect against GLP by a factor of approximately 1500, resulting in an IC50 of 75 μM. E67-2 has much reduced inhibition on PHF8 on the doubly methylated H3(1-24)K4me3K9me2 peptide substrate. E67-2 (100~100000 nM; 24 hours; fibroblasts) has significantly reduced cell toxicity .
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体内实验——
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同义词——
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通路Chromatin/Epigenetic
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靶点Histone Demethylase
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受体Histone Demethylase
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研究领域——
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适应症——
化学信息
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CAS Number1364914-62-4
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分子量404.559
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分子式C21H36N6O2
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称7-((5-aminopentyl)oxy)-N2-(3-(dimethylamino)propyl)-6-methoxy-N4,N4-dimethylquinazoline-2,4-diamine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Upadhyay AK, et al. J Mol Biol. 2012 Feb 24;416(3):319-27.
