E235

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

E235 是一种激活转录因子 4 (ATF4) 的表达调节剂。E235 通过激活综合应激反应 (ISR) 和 DNA 损伤应答信号降低细胞的活力。E235 具有抗增殖活性，可用于肿瘤研究。

E235 is an expression regulator of activates transcription factor 4 (ATF4). E235 reduces cell viability by activating integrated stress response (ISR) and DNA damage response signals. E235 has anti-proliferative activity and can be used for tumor research.

Western Blot Analysis Cell Line:HT1080, B16F10 and AG1522 cells.Concentration:0, 1, 5 and 10 μM.Incubation Time:4 h.Result:Increased the expression of ATF4 with dose-dependent manner.Western Blot Analysis Cell Line:HT1080 cells.Concentration:0, 0.5, 1, 5 or 10 μM.Incubation Time:2, 4 or 8 h.Result:Increased the expression of p-elF2α with time and dose dependent manner.Cell Proliferation Assay Cell Line:HT1080 or RPMI-8226 cells.Concentration:1 μM.Incubation Time:0, 8, 16 and 24 h.Result:Exhibited anti-proliferative activity.Cell Viability Assay Cell Line:AG1522 cells.Concentration:0, 0.1, 0.5, 1 and 10 μM.Incubation Time:4 d. Result:Inhibited cell viability with dose-dependent manner.Cell Cycle AnalysisCell Line:HT1080 cells and B16F10 cells.Concentration:1 μM.Incubation Time:8, 16 and 24 h.Result:Caused cell arrest during G2/M phase.

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Others

Other Targets

Others

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891894-69-2

484.59

C28H25FN4OS

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 10 mg/mL (20.64 mM; 超声助溶 (<60°C); H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

O=C(NC1CCN(CC=2C=CC=CC2)CC1)C3=CC=C4C(SC5=NC(=CN54)C=6C=CC(F)=CC6)=C3

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(-20℃)

With Ice Pack

≥ 2 years