Dup-721 ( —— )

产品货号. M28176 CAS No. 104421-21-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Dup-721
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis.
产品描述

DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis.(In Vitro):DuP-721 (1.5-4 μg/ml) inhibits equally the strains of Mycobacterium tuberculosis susceptible and resistant to conventional antituberculosis drug. And it does not show cross resistance to any of the anti-tuberculosis drugs tested.DuP-721 is inactive against M. avium and M. intracellulare at 250 μg/ml. It inhibits M. gordonoe and M. fortuitum at 3.9 μg/ml and M. kansassi and M. scrofulaceum at 1.95 μg/ml and 15.6 μg/ml, respectively.(In Vivo):DuP-721 (oral gavage; 50-160 mg/kg) is protective against M. tuberculosis infection in mice. DuP-721 protects 100% of the infected animals at 50 mg/kg p.o. dose when administered daily for 17 days, and the same effect is observed at 160 mg/kg dose when the drug is administered only on day 11 and 12 post infection.
同义词

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通路

GPCR/G Protein
靶点

Antibacterial
受体

Nuclear factor of activated Tcells (NFAT)
研究领域

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适应症

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1.Colin A Bretz,?et al. The role of the NFAT signaling pathway in retinal neovascularization. Invest Ophthalmol Vis Sci.?2013 Oct 25;54(10):7020-7.

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