Dopamine ( —— )

产品货号. M24487 CAS No. 51-61-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Dopamine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

多巴胺是一种正性血管加压剂和多巴胺受体激动剂，用于神经系统疾病。
产品描述

Dopamine is an inotropic vasopressor agent and dopamine receptor agonist used in neurological diseases.?
体外实验

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) strongly stimulates human umbilical vein endothelial cells (HUVECs) proliferation. The stimulatory effect of VPF/VEGF is abrogated by Dopamine (1 μM; 24hours). Cell Proliferation Assay Cell Line:HUVECs Concentration:1 μMIncubation Time:24 hours Result:Inhibited VPF/VEGF-induced HUVEC proliferation specifically through its D2 receptor.
体内实验

Dopamine (50 mg/kg; i.p. injection; days 1-7) strongly and selectively inhibits the vascular permeabilizing and angiogenic activities of VPF/VEGF. Animal Model:Syngeneic C3Heb/FeJ mice with MOT ascites tumors Dosage:50 mg/kg Administration:I.p. injection; 7 days Result:Corresponding to ~5% of the median lethal dose (LD50) in mice) beginning at 24 hours after tumor-cell injection and continuing daily for 7 days.
同义词

——
通路

GPCR/G Protein
靶点

Dopamine Receptor
受体

dopamine
研究领域

——
适应症

——

1.Berke, Joshua D . What does dopamine mean?[J]. Nature Neuroscience, 2018.

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