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Dianemycin

CAS No. 35865-33-9

Dianemycin ( Nanchangmycin (free acid) )

产品货号. M21964 CAS No. 35865-33-9

Dianemycin 是一种广谱聚醚抗生素,抑制革兰氏阳性菌。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥725 有现货
5MG ¥1121 有现货
10MG ¥1872 有现货
50MG ¥5569 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Dianemycin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Dianemycin 是一种广谱聚醚抗生素,抑制革兰氏阳性菌。
  • 产品描述
    Dianemycin is a broad spectrum polyether antibiotic, inhibits gram-positive bacteria.?Nanchangmycin is a broad spectrum antiviral active against Zika virus
  • 体外实验
    Dianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Dianemycin is active against drug resistant strains of malaria. Dianemycin (Nanchangmycin) as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Dianemycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Dianemycin has low toxicity in these ranges. In addition, DENV is inhibited by Dianemycin across cell types.
  • 体内实验
    ——
  • 同义词
    Nanchangmycin (free acid)
  • 通路
    GPCR/G Protein
  • 靶点
    Antibacterial
  • 受体
    Bacterial
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    35865-33-9
  • 分子量
    867.11
  • 分子式
    C47H78O14
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:150 mg/ml(172.99 mM; Need ultrasonic)
  • SMILES
    [H][C@@]1(C[C@H](O[C@@H]2CC[C@H](OC)[C@@H](C)O2)[C@@H](C)[C@@]2(O[C@H](C[C@@H]2C)[C@@]2([H])O[C@@](O)(CO)[C@H](C)C[C@@H]2C)O1)[C@]1(C)CC[C@]2(C[C@H](O)[C@@H](C)[C@]([H])(O2)[C@@H](C)\C=C(/C)C(=O)[C@H](C)C[C@H](C)C(O)=O)O1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Hamill R L , Hoenh M M , Pittenger G E , et al. DIANEMYCIN, AN ANTIBIOTIC OF THE GROUP AFFECTING ION TRANSPORT[J]. The Journal of Antibiotics, 1969, 22(4):161-164.2. Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815.3. Liu T, et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic Nanchangmycin. Chem Biol. 2008 May;15(5):449-58.
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