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Deltonin

CAS No. 55659-75-1

Deltonin ( —— )

产品货号. M19433 CAS No. 55659-75-1

Deltonin 具有抑制 ERK1/2 和 AKT 激活的作用。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥2535 有现货
10MG ¥3791 有现货
25MG ¥6099 有现货
50MG ¥7995 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Deltonin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Deltonin 具有抑制 ERK1/2 和 AKT 激活的作用。
  • 产品描述
    Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM) mouse C26 cells (IC50: 1.22 μM) and human MDA-MB-231 cells (IC50: 1.58 μM).
  • 体外实验
    Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC50s of 1.3, 1.29, 2.11 and 1.22 μM. Deltonin also causes G2-M phase arrest and induces apoptosis in C26 cells.Deltonin (0-5 μM) decreases the phosphorylation of AKT and ERK1/2 levels in MDA-MB-231 cells. Deltonin (0.5-8 μM) also dose-dependently inhibits the proliferation, and causes apoptosis with ROS production in MDA-MB-231 cells.
  • 体内实验
    Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    55659-75-1
  • 分子量
    885.05
  • 分子式
    C45H72O17
  • 纯度
    >98% (HPLC)
  • 溶解度
    Water
  • SMILES
    O[C@@H]9[C@H](O)[C@@H](O)[C@H](C)O[C@H]9O[C@@H]8[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@@H](CO)O[C@H]8O[C@@H]6CC7=CC[C@@H]3[C@H](CC[C@]4(C)[C@H]5[C@H](C)[C@@]2(CC[C@@H](C)CO2)O[C@H]5C[C@@H]34)[C@@]7(C)CC6
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Tong QY et al. Deltonin a steroidal saponin inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis. Cell Physiol Biochem. 2011;27(3-4):233-42.
产品手册
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