Deltonin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Deltonin 具有抑制 ERK1/2 和 AKT 激活的作用。

Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM) mouse C26 cells (IC50: 1.22 μM) and human MDA-MB-231 cells (IC50: 1.58 μM).

Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC50s of 1.3, 1.29, 2.11 and 1.22 μM. Deltonin also causes G2-M phase arrest and induces apoptosis in C26 cells.Deltonin (0-5 μM) decreases the phosphorylation of AKT and ERK1/2 levels in MDA-MB-231 cells. Deltonin (0.5-8 μM) also dose-dependently inhibits the proliferation, and causes apoptosis with ROS production in MDA-MB-231 cells.

Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice.

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Other Targets

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55659-75-1

885.05

C45H72O17

>98% (HPLC)

Water

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(-20℃)

With Ice Pack

≥ 2 years