
Deltonin
CAS No. 55659-75-1
Deltonin ( —— )
产品货号. M19433 CAS No. 55659-75-1
Deltonin 具有抑制 ERK1/2 和 AKT 激活的作用。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2535 | 有现货 |
![]() ![]() |
10MG | ¥3791 | 有现货 |
![]() ![]() |
25MG | ¥6099 | 有现货 |
![]() ![]() |
50MG | ¥7995 | 有现货 |
![]() ![]() |
100MG | 获取报价 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称Deltonin
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Deltonin 具有抑制 ERK1/2 和 AKT 激活的作用。
-
产品描述Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM) mouse C26 cells (IC50: 1.22 μM) and human MDA-MB-231 cells (IC50: 1.58 μM).
-
体外实验Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC50s of 1.3, 1.29, 2.11 and 1.22 μM. Deltonin also causes G2-M phase arrest and induces apoptosis in C26 cells.Deltonin (0-5 μM) decreases the phosphorylation of AKT and ERK1/2 levels in MDA-MB-231 cells. Deltonin (0.5-8 μM) also dose-dependently inhibits the proliferation, and causes apoptosis with ROS production in MDA-MB-231 cells.
-
体内实验Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice.
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体Others
-
研究领域——
-
适应症——
化学信息
-
CAS Number55659-75-1
-
分子量885.05
-
分子式C45H72O17
-
纯度>98% (HPLC)
-
溶解度Water
-
SMILESO[C@@H]9[C@H](O)[C@@H](O)[C@H](C)O[C@H]9O[C@@H]8[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@@H](CO)O[C@H]8O[C@@H]6CC7=CC[C@@H]3[C@H](CC[C@]4(C)[C@H]5[C@H](C)[C@@]2(CC[C@@H](C)CO2)O[C@H]5C[C@@H]34)[C@@]7(C)CC6
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Tong QY et al. Deltonin a steroidal saponin inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis. Cell Physiol Biochem. 2011;27(3-4):233-42.
产品手册




关联产品
-
Koumine
Koumine具有抗肿瘤作用,可能成为未来乳腺癌的化疗剂。
-
Ulinastatin (b)
乌司他丁是一种尿胰蛋白酶抑制剂 (UTI),是一种从健康人尿液中分离或合成产生的糖蛋白。
-
2-Acetyl-6-methoxyna...
6'-Methoxy-2'-acetonaphthone 是一种生化试剂,可作为生物材料或有机化合物,用于生命科学相关研究。