Dehydroevodiamine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

脱氢吴茱萸碱是吴茱萸的一种成分，具有多种生物效应，如降血压、负变时、离子通道抑制剂、抑制一氧化氮产生和增强脑血流活性。

Dehydroevodiamine, a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.

Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expressionand prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS-induced increase in the iNOS and COX-2 mRNA expression.Western Blot Analysis Cell Line:RAW 264.7 macrophage cells Concentration:10 μM, 30 μM, 50 μM Incubation Time:pretreated 2 hours Result:Reduced iNOS and COX-2 expression and increased IκB-α expression.RT-PCR Cell Line:RAW 264.7 macrophage cells Concentration:10 μM, 30 μM, 50 μM Incubation Time:pretreated 2 hours Result:Reduced iNOS and COX-2 mRNA expression.

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GPCR/G Protein

Dopamine Receptor

Others

Others-Field

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67909-49-3

301.34

C19H15N3O

>98% (HPLC)

In Vitro:?DMSO : 8.33 mg/mL (27.64 mM)

CN1C2=CC=CC=C2C(=O)N3C1=C4C(=C5C=CC=CC5=N4)CC3

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(-20℃)

With Ice Pack

≥ 2 years