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Danirixin
CAS No. 954126-98-8
Danirixin ( GSK-1325756 )
产品货号. M16816 CAS No. 954126-98-8
Danirixin (GSK-1325756) 是一种高亲和力、选择性和可逆的 CXCR2 拮抗剂 (IC50=12.5 nM, CXCL8)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2001 | 有现货 |
|
| 10MG | ￥2819 | 有现货 |
|
| 25MG | ￥4763 | 有现货 |
|
| 50MG | ￥6788 | 有现货 |
|
| 100MG | ￥9396 | 有现货 |
|
| 500MG | ￥18792 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Danirixin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Danirixin (GSK-1325756) 是一种高亲和力、选择性和可逆的 CXCR2 拮抗剂 (IC50=12.5 nM, CXCL8)。
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产品描述Danirixin (GSK-1325756) is a high-affinity, selective and reversible CXCR2 antagonist (IC50=12.5 nM, CXCL8); blocks the CD11b upregulation with pIC50 of 6.05 and 6.3, respectively, in rat and human whole-blood studies; blocks the influx of neutrophils into the lung in vivo in rats following aerosol lipopolysaccharide (ED50=1.4 mg/kg); orally active.COPD Phase 2 Clinical(In Vitro):Danirixin is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine.
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体外实验Danirixin is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine.
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体内实验——
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同义词GSK-1325756
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通路GPCR/G Protein
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靶点Chemokine Receptor
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受体CXCL8-CXCR2
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研究领域Inflammation/Immunology
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适应症COPD
化学信息
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CAS Number954126-98-8
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分子量441.9041
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分子式C19H21ClFN3O4S
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纯度>98% (HPLC)
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溶解度DMSO: 8 mg/mL
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SMILESClC(C(S([C@H]1CCCNC1)(=O)=O)=C2O)=CC=C2NC(NC3=CC=CC(F)=C3C)=O
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化学全称Urea, N-[4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N'-(3-fluoro-2-methylphenyl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bloomer JC, et al. Eur J Pharm Biopharm. 2017 Apr 3. pii: S0939-6411(16)31009-8.
2. Miller BE, et al. BMC Pharmacol Toxicol. 2015 Jun 20;16:18.
3. Busch-Petersen J, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):338-346.
