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DS-7423
CAS No. 1222104-37-1
DS-7423 ( DS7423 | DS 7423 )
产品货号. M10844 CAS No. 1222104-37-1
DS-7423 是一种新型强效小分子 PI3K/mTOR 双重抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3013 | 有现货 |
|
| 10MG | ￥4504 | 有现货 |
|
| 25MG | ￥7258 | 有现货 |
|
| 50MG | ￥9882 | 有现货 |
|
| 100MG | ￥13365 | 有现货 |
|
| 500MG | ￥26649 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称DS-7423
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DS-7423 是一种新型强效小分子 PI3K/mTOR 双重抑制剂。
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产品描述DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR? respectively; exerts anti-tumor effect against a panel of nine OCCA cell lines with IC50 of <75 nM, regardless of the mutational status of PIK3CA; suppresses the tumor growth of OCCA in a dose-dependent manner in mouse xenograft models.Solid Tumors Phase 1 Discontinued.
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体外实验DS-7423 increases TP53 expression, the level of p-TP53 on Ser-46, and induced apoptosisrelated TP53 target genes (TP53AIP1 and PUMA) in OCCC cells.DS-7423 also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM).
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体内实验——
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同义词DS7423 | DS 7423
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通路PI3K/Akt/mTOR signaling
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靶点PI3K
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受体PI3K
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研究领域Cancer
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适应症Solid Tumors
化学信息
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CAS Number1222104-37-1
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分子量520.52
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分子式C22H27F3N10O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (192.12 mM)
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SMILES——
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化学全称(R)-1-(4-(2-(2-aminopyrimidin-5-yl)-6-morpholino-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl)-2-methylpiperazin-1-yl)ethan-1-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Koul D, et al. Oncotarget. 2017 Mar 28;8(13):21741-21753.
2. Kashiyama T, et al. PLoS One. 2014 Feb 4;9(2):e87220.
