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DORA-22
CAS No. 1088991-95-0
DORA-22 ( —— )
产品货号. M22081 CAS No. 1088991-95-0
DORA-22 是一种双重食欲素受体拮抗剂，可改善轻度压力诱发的失眠，对记忆力影响极小DORA-22 是一种双重食欲素受体拮抗剂，可改善轻度压力诱发的失眠，对记忆力影响极小。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1604 | 有现货 |
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| 5MG | ￥2414 | 有现货 |
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| 10MG | ￥3669 | 有现货 |
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| 25MG | ￥6051 | 有现货 |
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| 50MG | ￥8505 | 有现货 |
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| 100MG | ￥11502 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称DORA-22
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DORA-22 是一种双重食欲素受体拮抗剂，可改善轻度压力诱发的失眠，对记忆力影响极小DORA-22 是一种双重食欲素受体拮抗剂，可改善轻度压力诱发的失眠，对记忆力影响极小。
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产品描述DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memoryDORA-22, a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory.DORA-22 treatment improved the insomnia-related sleep disruption-wake was attenuated and NREM sleep was normalized.?REM sleep amounts were enhanced compared with vehicle treatment for one dose (30 mg/kg).?In the first hour of insomnia model exposure, DORA-22 promoted the number and average duration of NREM sleep spindles, which have been previously proposed to play a role in memory consolidation (all doses).?Water maze measures revealed probe trial performance improvement for select doses of DORA-22, including increased time spent in the platform quadrant (10 and 30 mg/kg) and time spent in platform location and number of platform crossings (10 mg/kg only).?In conclusion, DORA-22 treatment improved insomnia-related sleep disruption and memory consolidation deficits.
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体外实验——
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体OX Receptor
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研究领域——
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适应症——
化学信息
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CAS Number1088991-95-0
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分子量424.4
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分子式C23H22F2N4O2?
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纯度>98% (HPLC)
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溶解度——
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SMILESC[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(F)ccc1-c1ncccn1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Gamble M C , Katsuki F , Mccoy J G , et al. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model[J]. Sleep, 2019.
