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DORA-22

CAS No. 1088991-95-0

DORA-22 ( —— )

产品货号. M22081 CAS No. 1088991-95-0

DORA-22 是一种双重食欲素受体拮抗剂,可改善轻度压力诱发的失眠,对记忆力影响极小DORA-22 是一种双重食欲素受体拮抗剂,可改善轻度压力诱发的失眠,对记忆力影响极小。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥1604 有现货
5MG ¥2414 有现货
10MG ¥3669 有现货
25MG ¥6051 有现货
50MG ¥8505 有现货
100MG ¥11502 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    DORA-22
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    DORA-22 是一种双重食欲素受体拮抗剂,可改善轻度压力诱发的失眠,对记忆力影响极小DORA-22 是一种双重食欲素受体拮抗剂,可改善轻度压力诱发的失眠,对记忆力影响极小。
  • 产品描述
    DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memoryDORA-22, a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory.DORA-22 treatment improved the insomnia-related sleep disruption-wake was attenuated and NREM sleep was normalized.?REM sleep amounts were enhanced compared with vehicle treatment for one dose (30 mg/kg).?In the first hour of insomnia model exposure, DORA-22 promoted the number and average duration of NREM sleep spindles, which have been previously proposed to play a role in memory consolidation (all doses).?Water maze measures revealed probe trial performance improvement for select doses of DORA-22, including increased time spent in the platform quadrant (10 and 30 mg/kg) and time spent in platform location and number of platform crossings (10 mg/kg only).?In conclusion, DORA-22 treatment improved insomnia-related sleep disruption and memory consolidation deficits.
  • 体外实验
    ——
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    OX Receptor
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1088991-95-0
  • 分子量
    424.4
  • 分子式
    C23H22F2N4O2?
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(F)ccc1-c1ncccn1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Gamble M C , Katsuki F , Mccoy J G , et al. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model[J]. Sleep, 2019.
产品手册
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