DO34

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DO34 是一个强效的、选择性的、具有中枢活性的二酰基甘油脂肪酶 (DAGL) 抑制剂，其对 DAGLα 转换的 IC50 值为 6 nM，对 DAGLβ 的IC50 值为 3-8 nM。

DO34 is a highly potent, selective and centrally active diacylglycerol lipase (DAGL) inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG, and an IC50 for DAGLβ.

DO34 is a highly potent, selective and centrally active DAGL inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG, as determined using a real-time, fluorescence-based natural substrate assay with membrane lysates from HEK293T cells expressing recombinant human DAGLα. It is also confirmed that and DO34 is a potent inhibitor of DAGLβ with IC50 of 3-8 nM.

DO34 (compound 39) prevents fasting-induced refeeding of mice, which is typical cannabinoid CB1-receptor mediated behavior. DO34 (comound 39) reduces brain 2-AG levels in dose- and time dependent manner. DO34 could block the tonic CB1 activation. AM251 significantly increases basal PF-EPSCs in MAGL-TKO mice, and the effect of AM251 is blocked by the DAGL inhibitor DO34.

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Others

Other Targets

Others

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1848233-58-8

531.53

C26H28F3N5O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 100 mg/mL (188.14 mM )

O=C(OC(C)(C)C)N1CCN(C(=O)N2N=NC(=C2)C=3C=CC(OC(F)(F)F)=CC3)C(CC=4C=CC=CC4)C1

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(-20℃)

With Ice Pack

≥ 2 years