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DMX-5804
CAS No. 2306178-56-1
DMX-5804 ( DMX5804 | DMX 5804 )
产品货号. M13644 CAS No. 2306178-56-1
DMX-5804 (DMX5804) 是一种有效的选择性 MAP4K4 小分子抑制剂，IC50 为 3 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1272 | 有现货 |
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| 5MG | ￥2001 | 有现货 |
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| 10MG | ￥3216 | 有现货 |
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| 25MG | ￥5370 | 有现货 |
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| 50MG | ￥7655 | 有现货 |
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| 100MG | ￥10368 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称DMX-5804
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DMX-5804 (DMX5804) 是一种有效的选择性 MAP4K4 小分子抑制剂，IC50 为 3 nM。
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产品描述DMX-5804 (DMX5804) is a potent, selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM; displays >100-fold selectivity over GCK/MAP4K2, GLK/MAP4K3, KHS/MAP4K5 and VEGFR; rescues cell survival, mitochondrial function, and calcium cycling in hiPSC-CMs (human induced-pluripotent-stem-cell-derived cardiomyocytes), protects hiPSC-CMs with EC50 of 500 nM for cell death induced by 400 uM H2O2; reduces infarct size and ischemia-reperfusion injury in mice in mice.
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体外实验DMX-5804 exhibits great selectivity at MAP4K4 over other kinases, such as GCK/MAP4K2 (pIC50, 6.50), GLK/MAP4K3 (pIC50, 4.95), KHS/MAP4K5 (pIC50, 6.36), ABL1 (pIC50, 5.80), Aurora B (pIC50, 5.49), FLT3 (pIC50, 5.31), GSK3β (pIC50, 4.66), MLK1/MAP3K9 (pIC50, 7.19), MLK3/MAP3K11 (pIC50, 6.99), NUAK (pIC50, 6.88) and VEGFR (pIC50, 5.72).
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体内实验——
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同义词DMX5804 | DMX 5804
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通路MAPK/ERK Signaling
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靶点MAP4K
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受体MAP4K
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研究领域——
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适应症——
化学信息
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CAS Number2306178-56-1
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分子量361.401
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分子式C21H19N3O3
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纯度>98% (HPLC)
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溶解度DMSO : 125 mg/mL 345.89 mM
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SMILESO=C1NC=NC2=C1C(C3=CC=C(OCCOC)C=C3)=CN2C4=CC=CC=C4
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化学全称5-(4-(2-methoxyethoxy)phenyl)-7-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Fiedler LR, et al. Cell Stem Cell. 2019 Mar 1. pii: S1934-5909(19)30013-X.
