DHFR-IN-4

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DHFR-IN-4 是一种有效的二氢叶酸还原酶 (DHFR) 抑制剂IC50 为 123 nM。DHFR-IN-4 对 EGFR 和 HER2 也具有抑制活性，IC50 分别为 246 nM 和 357 nM。DHFR-IN-4 对癌细胞具有显著的广谱细胞毒性活性。

DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with an IC50 value of 123 nM. DHFR-IN-4 also has inhibitory activity against EGFR and HER2 with IC50s of 246 nM and 357 nM, respectively. DHFR-IN-4 has remarkable broad spectrum cytotoxic potency against cancer cells.

DHFR-IN-4 (compound 42) (0-100 μM; 72 h) shows remarkable broad spectrum cytotoxic potency against HepG2, MCF-7, HCT-116, PC3 and HeLa.Cell Cytotoxicity Assay Cell Line:HepG2, MCF-7, HCT-116, PC3 and HeLa Concentration:0-100 μM Incubation Time:72 h Result:Exhibited antiproliferative activity against HepG2, MCF-7, HCT-116, PC3 and HeLa with IC50s of 9.67±0.7 μM, 8.46±0.7 μM, 13.24±0.9 μM, 11.17±1.0 μM and 6.90±0.5 μM.

——

——

Cell Cycle/DNA Damage

DHFR

DHFR

——

——

2820126-49-4

371.46

C18H21N5O2S

>98% (HPLC)

——

O=C(NN)C1=CSC2=NC(=C(C=3C=CC(=CC3)C)N21)CN4CCOCC4

——

(-20℃)

With Ice Pack

≥ 2 years