DG172 (dihydrochloride)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DG172（二盐酸盐）是 PPARβ/δ 的拮抗剂（IC50：27 nM）。

DG172 (dihydrochloride) is an ?antagonist of ?PPARβ/δ(IC50 : 27 nM).

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC50, 9.5 nM). DG172 (1 μM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b+/Gr1+ granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation. DG172 (0.1, 1.0 μM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells.

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DG-172 dihydrochloride

Metabolic Enzyme/Protease

PPAR

PPAR

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1361504-77-9

455.2

C20H22BrCl2N3

>98% (HPLC)

H2O:14.29 mg/mL (31.39 mM; Need ultrasonic)

CN1CCN(c2ccc(/C=C(\C#N)c3ccccc3Br)cc2)CC1.Cl.Cl

(Z)-2-(2-bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride

(-20℃)

With Ice Pack

≥ 2 years