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DB818
CAS No. 790241-43-9
DB818 ( —— )
产品货号. M28983 CAS No. 790241-43-9
DB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3029 | 有现货 |
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| 10MG | ￥4528 | 有现货 |
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| 25MG | ￥7752 | 有现货 |
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| 50MG | ￥11664 | 有现货 |
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| 100MG | ￥17658 | 有现货 |
|
| 200MG | ￥26892 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称DB818
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression.
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产品描述DB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression.(In Vitro):In the three AML cell lines, DB818 suppressed growth, induced apoptosis, and down-regulated the expression of HOXA9 transcriptional target genes: MYB proto-oncogene, transcription factor (MYB), MYC proto-oncogene, bHLH transcription factor (MYC), and BCL2 apoptosis regulator (BCL2), while up-regulating that of Fos proto-oncogene, AP-1 transcription factor subunit (FOS). HOXA9 knockdown showed similar effects, except for MYC expression, which differed between DB818-treated and HOXA9-deficient OCI/AML3 cells, suggesting an off-target effect of DB818.
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number790241-43-9
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分子量360.4
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分子式C19H16N6S
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纯度>98% (HPLC)
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溶解度——
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SMILESNC(c(cc1)cc2c1nc(-c1ccc(-c3ccc(/C=N\N)cc3)s1)[nH]2)=N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Tomani JCD, et al. In Vitro Antiplasmodial and Cytotoxic Activities of Compounds from the Roots of Eriosema montanum Baker f. (Fabaceae). Molecules. 2021 May 10;26(9):2795.
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